By Erna E. Kritzinger
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Extra info for A Colour Atlas of Optic Disc Abnormalities
Adaptive Optics Adaptive optics (AO) appears to be a promising approach to correct ocular optical aberrations in order to improve transverse resolution. Over recent decades, AO is no longer confined to astronomy but is now applied in ocular optics with the use of deformable mirrors. The combination of AO and SD-OCT can allow an axial resolution of 3 μm and a transverse resolution of 3 μm with decreased diffraction, raising hopes for resolution at the cellular level. Numerous studies combining several technical improvements have allowed visualization of the interface, inner and outer segments, and the cone mosaic (Fernandez 200513, Zawadzki 200514, Zhang 200615).
Imaging of the internal structure of drusen is now possible and could be an indirect measurement of complement-related activity (Figure 13). However, this work has not yet been validated by clinical studies. These segmentation techniques can also be used to measure total drusen volume in the context of monitoring of disease progression and to assess the risk of progression (Figure 14). Computer-assisted analysis can be used to automate these studies. 25 Chapter 2 · Applications of Spectral-Domain OCT in AMD A ⊡ Figure 9A): Screenshot of the Duke OCT Retinal Analysis Program (DOCTRAP) and the Main Graphical User Interface (GUI).
The optimal method would be to fuse the information derived from these two imaging modalities, as with the Heidelberg SLO-OCT, T which captures autofluorescent imaging integrated with 3D SD-OCT volume. With SD-OCT, it is easier to differentiate between type 1 and type 2 membranes and to create a three-dimensional reconstruction of the neovascular complex and associated retinal lesions (Schmidt-Erfurth 2005 32). Once again, segmentation techniques allow correlation of RPE changes with changes of the overlying photoreceptor layer (Figure 16).
A Colour Atlas of Optic Disc Abnormalities by Erna E. Kritzinger