By D. Virgil Alfaro III et al.
- Learn from a popular workforce of retina surgeons who deal with all points of administration, together with anatomy, body structure, and pathophysiology; imaging of the macula in ARMD, prevention measures and remedy; and destiny instructions within the field.
- Gain an exceptional starting place in intravenous fluorescein angiography, indocyanine eco-friendly angiography, and optical coherence tomography, in addition to antiVEGE treatment and comparable new medicinal drugs, optimizing your analysis and therapy options.
- Understand the numerous switch within the class method of choroidal neovascular membranes in ARMD.
- Get updated info on treating ARMD secondary to geographic atrophy via phone transplantation and pharmacologic therapies.
- Easily visualize key points of ARMD because of high quality illustrations and photographs.
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Extra resources for Age-Related Macular Degeneration
Unfortunately, most double knockout mice die from a movement disorder at a very young age, thus hindering possibility to study long-term effects. Exogenous Oxidative Conditions: Cigarette Smoke, Hydroquinone, High-Fat Diet, and Blue Light It is unanimously accepted that smoking constitutes the major preventable risk factor for AMD (93–97). Cigarette smoke contains over 4,000 potentially damaging toxins, many of which are pro-oxidants including carbon monoxide, nitric oxide, and hydroquinone (98).
Latest studies have managed to optimize laser parameters to produce advanced lesions more frequently (232). Still, group sizes of 10 monkeys are typically required to document significant effects, and in some studies, smaller group sizes have generated inconclusive results (233,234). Laser Injury in Rabbits and Pigs Rabbit elDirini et al. (235) used rabbits in an attempt to find an intermediate laser-induced CNV model between rodents and primates, thereby avoiding the expense and ethical issues concerning the latter.
Overall, these models contrast with the murine models of wet AMD that are mostly induced mechanically and are explained later in this chapter. LIPID AND GLUCOSE METABOLISM MODELS A growing body of the literature indicates the involvement of lipids, lipoproteins, and glucose in the formation of extracellular lesions in aging BM, basal deposits and drusen, and other AMD hallmarks. Observational studies have indicated that maintaining adequate levels of fatty acids or a low glycemic index (GI) diet may be particularly beneficial for early stages of the disease.
Age-Related Macular Degeneration by D. Virgil Alfaro III et al.